Pandemic influenza A(H1N1) 2009 virus outbreak among boarding school pupils in Madagascar: compliance and adverse effects of prophylactic oseltamivir treatment.
Identifieur interne : 000B84 ( Main/Exploration ); précédent : 000B83; suivant : 000B85Pandemic influenza A(H1N1) 2009 virus outbreak among boarding school pupils in Madagascar: compliance and adverse effects of prophylactic oseltamivir treatment.
Auteurs : Soatiana Rajatonirina [Madagascar] ; Jean-Michel Heraud [Madagascar] ; Laurence Randrianasolo [Madagascar] ; Norosoa Razanajatovo [Madagascar] ; Tombo Ramandimbisoa [Madagascar] ; Maherisoa Ratsitorahina [Madagascar] ; Vincent Richard [Madagascar]Source :
- Journal of Infection in Developing Countries [ 2036-6590 ] ; 2011.
Abstract
INTRODUCTION: In October 2009, the first outbreak of pandemic influenza A(H1N1) 2009 virus in Madagascar occurred at a school in Antananarivo. Among the first 12 cases, five were reported in boarding pupils at the school. The school closed 10 days into the outbreak. Mass oseltamivir prophylactic treatment was used to contain the outbreak. This study aimed to determine the transmission of infection among boarding school pupils and to evaluate the adverse effects of oseltamivir chemoprophylactic treatment and their impact on compliance. METHODOLOGY: After conducting an initial investigation of the outbreak we administered a questionnaire to 132 boarders who were present after the school re-opened. Questions addressed symptoms of influenza-like illness, compliance with chemoprophylaxis, and adverse effects. RESULTS: Of 59 boarders, 20 (45.0%) had confirmed pandemic influenza A (H1N1) infection. Among the asymptomatic boarders, compliance with oseltamivir chemoprophylaxis was moderate: 56.2% took the full 10-day course, and 66.9% completed at least seven days. In contrast, among symptomatic boarders, only two did not take the full course of oseltamivir. Fifty percent of the boarders receiving oseltamivir experienced symptoms such as fatigue (38.7%), difficulty concentrating (22.6%) and headaches (19.4%). Bad compliance was not associated with adverse effects. CONCLUSION: Since the symptoms of pandemic influenza A(H1N1) 2009 virus were generally mild, the burden of adverse effects must be considered when deciding on mass oseltamivir chemoprophylaxis among teenagers.
Url:
DOI: 10.3855/jidc.1318
Affiliations:
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sortKey="Ramandimbisoa, Tombo" sort="Ramandimbisoa, Tombo" uniqKey="Ramandimbisoa T" first="Tombo" last="Ramandimbisoa">Tombo Ramandimbisoa</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-154577" status="INCOMING"> <orgName>School health service</orgName> <desc> <address> <addrLine>Antananarivo</addrLine> <country key="MG"></country> </address> </desc> <listRelation> <relation active="#struct-338966" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-338966" type="direct"><org type="institution" xml:id="struct-338966" status="INCOMING"> <orgName>School health service</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Madagascar</country></affiliation></author><author><name sortKey="Ratsitorahina, Maherisoa" sort="Ratsitorahina, Maherisoa" uniqKey="Ratsitorahina M" first="Maherisoa" last="Ratsitorahina">Maherisoa Ratsitorahina</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-55578" status="VALID"> <orgName>Institut Pasteur de Madagascar</orgName> <desc> <address> <addrLine>B.P. 1274 Antananarivo</addrLine> <country key="MG"></country> </address> <ref type="url">http://www.pasteur.mg</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Madagascar</country></affiliation></author><author><name sortKey="Richard, Vincent" sort="Richard, Vincent" uniqKey="Richard V" first="Vincent" last="Richard">Vincent Richard</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-55578" status="VALID"> <orgName>Institut Pasteur de Madagascar</orgName> <desc> <address> <addrLine>B.P. 1274 Antananarivo</addrLine> <country key="MG"></country> </address> <ref type="url">http://www.pasteur.mg</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Madagascar</country></affiliation></author></analytic><idno type="DOI">10.3855/jidc.1318</idno><series><title level="j">Journal of Infection in Developing Countries</title><idno type="ISSN">2036-6590</idno><imprint><date type="datePub">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="es"><term>Influenza A(H1N1)v</term><term>Madagascar</term><term>boarders</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>INTRODUCTION: In October 2009, the first outbreak of pandemic influenza A(H1N1) 2009 virus in Madagascar occurred at a school in Antananarivo. Among the first 12 cases, five were reported in boarding pupils at the school. The school closed 10 days into the outbreak. Mass oseltamivir prophylactic treatment was used to contain the outbreak. This study aimed to determine the transmission of infection among boarding school pupils and to evaluate the adverse effects of oseltamivir chemoprophylactic treatment and their impact on compliance. METHODOLOGY: After conducting an initial investigation of the outbreak we administered a questionnaire to 132 boarders who were present after the school re-opened. Questions addressed symptoms of influenza-like illness, compliance with chemoprophylaxis, and adverse effects. RESULTS: Of 59 boarders, 20 (45.0%) had confirmed pandemic influenza A (H1N1) infection. Among the asymptomatic boarders, compliance with oseltamivir chemoprophylaxis was moderate: 56.2% took the full 10-day course, and 66.9% completed at least seven days. In contrast, among symptomatic boarders, only two did not take the full course of oseltamivir. Fifty percent of the boarders receiving oseltamivir experienced symptoms such as fatigue (38.7%), difficulty concentrating (22.6%) and headaches (19.4%). Bad compliance was not associated with adverse effects. CONCLUSION: Since the symptoms of pandemic influenza A(H1N1) 2009 virus were generally mild, the burden of adverse effects must be considered when deciding on mass oseltamivir chemoprophylaxis among teenagers.</p> </div></front></TEI><affiliations><list><country><li>Madagascar</li></country></list><tree><country name="Madagascar"><noRegion><name sortKey="Rajatonirina, Soatiana" sort="Rajatonirina, Soatiana" uniqKey="Rajatonirina S" first="Soatiana" last="Rajatonirina">Soatiana Rajatonirina</name></noRegion><name sortKey="Heraud, Jean Michel" sort="Heraud, Jean Michel" uniqKey="Heraud J" first="Jean-Michel" last="Heraud">Jean-Michel Heraud</name><name sortKey="Ramandimbisoa, Tombo" sort="Ramandimbisoa, Tombo" uniqKey="Ramandimbisoa T" first="Tombo" last="Ramandimbisoa">Tombo Ramandimbisoa</name><name sortKey="Randrianasolo, Laurence" sort="Randrianasolo, Laurence" uniqKey="Randrianasolo L" first="Laurence" last="Randrianasolo">Laurence Randrianasolo</name><name sortKey="Ratsitorahina, Maherisoa" sort="Ratsitorahina, Maherisoa" uniqKey="Ratsitorahina M" first="Maherisoa" last="Ratsitorahina">Maherisoa Ratsitorahina</name><name sortKey="Razanajatovo, Norosoa" sort="Razanajatovo, Norosoa" uniqKey="Razanajatovo N" first="Norosoa" last="Razanajatovo">Norosoa Razanajatovo</name><name sortKey="Richard, Vincent" sort="Richard, Vincent" uniqKey="Richard V" first="Vincent" last="Richard">Vincent Richard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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